Cholesterol Metabolism in a Murine Model of Vertical Sleeve Gastrectomy

Whang E, Ferrari A, Kennelly JP, Gao Y, Xiao X, Jarrett K, Bedard A, de Aguiar Vallim TQ, Tontonoz P.

bioRxiv 2025.07.03.659993; doi: https://doi.org/10.1101/2025.07.03.659993

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling.

Tol MJ*, Shimanaka Y*, Bedard AH, Sapia J, Cui L, Colaço-Gaspar M, Hofer P, Ferrari A, Qian K, Kennelly JP, Lee SD, Gao Y, Xiao X, Gao J, Mack JJ, Weston TA, Pan C, Lusis AJ, Williams KJ, Su B, Pike DP, Reed A, Milosevich N, Cravatt BF, Arita M, Young SG, Ford DA, Zechner R, Vanni S, Tontonoz P.

Nat Metab. 2025 Jul;7(7):1424-1442.

PMID: 40579620.

bioRxiv 2024.10.25.620374; doi: https://doi.org/10.1101/2024.10.25.620374

PMCID: PMC11565995

PPARa regulates ER-lipid droplet protein Calsyntenin-3b to promote ketogenesis in hepatocytes.

Uchiyama LF, Nguyen A, Qian K, Cui L, Pham KT, Xiao X, Gao Y, Shimanaka Y, Tol MJ, Vergnes L, Reue K, Tontonoz P.

Proc Natl Acad Sci U S A. 2025. Apr 29;122(17):e2426338122.

PMCID: PMC12054784

Cholesterol binding to VCAM-1 promotes vascular inflammation.

Kennelly JP*, Xiao X*, Gao Y, Kim S, Hong S-G, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P.

bioRxiv 2024.09.17.613543; doi: https://doi.org/10.1101/2024.09.17.613543.

PMCID: PMC11429921

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption.

Gao Y*, Kennelly JP*, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young S, Bensinger SJ, Tontonoz P.

bioRxiv 2024.03.08.584164; doi: https://doi.org/10.1101/2024.03.08.584164.

PMCID: PMC10979874

Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity.

Xiao X, Kennelly JP, Feng AC, Cheng L, Romartinez-Alonso B, Bedard AH, Gao Y, Cui L, Young SG, Schwabe JW, Tontonoz P.

J Clin Invest. 2024 Jan 4:e173002.

PMCID: PMC10866650

Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.

Ferrari A*, Whang E*, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P.

Science.2023 Nov 10;382(6671):eadf0966.

PMCID: PMC11073449

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity.

Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY.

Sci Immunol. 2023 Mar 10;8(81):eabo2003.

PMCID: PMC10080670

Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.

Xiao X*, Kennelly JP*, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P.

Nat Metab.2023 Jan;5(1):165-181.

PMCID: PMC9995220

Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells.

McDaniel MM, Chawla AS, Jain A, Meibers HE, Saha I, Gao Y, Jain V, Roskin K, Way SS, Pasare C.

Sci Immunol. 2022 Jan 21;7(67):eabk0182.

PMCID: PMC9036191

Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs.

Bideyan L, López Rodríguez M, Priest C, Kennelly JP, Gao Y, Ferrari A, Rajbhandari P, Feng AC, Tevosian SG, Smale ST, Tontonoz P.

Genes Dev. 2022 Nov-Dec 1;36(21-24):1129-1144.

PMCID: PMC9851399

IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility.

Song R, Gao Y, Dozmorov I, Malladi V, Saha I, McDaniel MM, Parameswaran S, Liang C, Arana C, Zhang B, Wakeland B, Zhou J, Weirauch MT, Kottyan LC, Wakeland EK, Pasare C.

Cell Rep. 2021 Mar 23;34(12):108891.

PMCID: PMC8300000

Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.

Raj P, Song R, Zhu H, Riediger L, Jun DJ, Liang C, Arana C, Zhang B, Gao Y, Wakeland BE, Dozmorov I, Zhou J, Kelly JA, Lauwerys BR, Guthridge JM, Olsen NJ, Nath SK, Pasare C, van Oers N, Gilkeson G, Tsao BP, Gaffney PM, Gregersen PK, James JA, Zuo X, Karp DR, Li QZ, Wakeland EK.

Genome Biol. 2020 Nov 19;21(1):281.

PMCID: PMC7677828

Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.

Gao Y, Deason K, Jain A, Irizarry-Caro RA, Dozmorov I, Coughlin LA, Rauch I, Evers BM, Koh AY, Wakeland EK, Pasare C.

J Exp Med. 2020 Apr 6;217(4):e20190476.

PMCID: PMC7144520

MyD88 Signaling in T Cells Is Critical for Effector CD4 T Cell Differentiation following a Transitional T Follicular Helper Cell Stage.

Mandraju R, Jain A, Gao Y, Ouyang Z, Norgard MV, Pasare C.

Infect Immun. 2018 Apr 23;86(5):e00791-17.

PMCID: PMC5913836

Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus.

Levitz R, Gao Y, Dozmorov I, Song R, Wakeland EK, Kahn JS.

PLoS One. 2017 Sep 6;12(9):e0184318.

PMCID: PMC5587315

Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation.

Hu W, Jain A, Gao Y, Dozmorov IM, Mandraju R, Wakeland EK, Pasare C.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13994-9.

PMCID: PMC4653191